You can fly to Lesvos from Heathrow, Gatwick and Manchester airports.
Most holidaymakers will want to visit Lesvos during the main holiday season, in which case Thompson offer either package holidays or charter flight-only options (from Gatwick and Manchester) deals.
Greek airlines Olympic and Agean fly to Lesvos year round from Athens. Athens can be reached from the UK using Olympic (from Heathrow), Aegean (from Heathrow), British Airways (from Heathrow and Manchester), and easyJet (from Luton and Gatwick).
Prices vary depending on your route (direct charter or two flights via Athens) and time of year, but expect to pay between £170-350 per person for a return flight.
See here for 2010 flight information.
By sea
For those with the time, or already holidaying in Greece and fancy a few days or more on Lesvos (or another Greek island), there are regular ferries from the Greek mainland to most Greek islands.
Lesvos is served daily by a ferry which leaves Pireaus (Athens) in the evening and arrives in Mytilini early the following morning.
For further info see Lesvos.com.